Search results for " exit"

Periodic expression of cell-cycle regulators: A laboratory experiment proposal for students in molecular and cell biology

2018

This article describes a laboratory exercise designed for undergraduate students in the subject of "Regulation of cell proliferation" which allows the students to carry out a research experiment in an important field such as cell cycle control, and to be introduced to a widely used technique in molecular biology laboratories such as the western blot. The cell cycle is regulated by the succession of cyclin-CDK kinase activities. Activation and inactivation of different cyclin-CDK complexes depend on the control of their positive and negative regulators, cyclins and CDK inhibitors (CKIs), respectively. In this experiment, fluctuations in the level of mitotic cyclin Clb2 and CDK inhibitor Sic1…

Envelliment exitós a la Comunitat Valenciana

2016

espanolEl presente trabajo busca conocer que entienden las personas mayores valencianas por envejecer con exito. Se muestran los resultados de la validacion, para una muestra espanola de un modelo de envejecimiento con exito, en relacion al contexto de la Comunitat Valenciana. Se realizo una investigacion cuantitativa con 593 personas de 60 anos y mas mayores (X# = 67.36 anos; S = 5.839), alumnos todos de la Universitat dels Majors (UNIMAJORS) de la Universitat de Valencia. La muestra (N=400) esta formada por 208 (67.5) mujeres y 192 (32.4) hombres. El ajuste empirico del modelo de envejecimiento con exito fue satisfactorio (χ2 (356)= 956.526; p Los resultados muestran que el funcionamiento…

Expression of the kinetochore protein Hec1 during the cell cycle in normal and cancer cells and its regulation by the pRb pathway.

2010

Highly Expressed in Cancer protein 1 (Hec1) is a subunit of the Ndc80 complex, a constituent of the mitotic kinetochore. HEC1 has been shown to be overexpressed in many cancers, suggesting that HEC1 upregulation is involved in the generation and/or maintenance of the tumour phenotype. However, the regulation of Hec1 expression in normal and tumour cells and the molecular alterations promoting accumulation of this protein in cancer cells are still unknown. Here we show that elevated Hec1 protein levels are characteristic of transformed cell lines of different origins and that kinetochore recruitment of this protein is also increased in cancer cell lines in comparison with normal human cells.…

The Legacy and the Tyranny of Time: Exit and Re-Entry of Sovereigns to International Capital Markets

2018

We use a novel continuous-time Weibull model (without and) with a change-point in the duration dependence parameter to investigate the duration of the exit and re-entry of sovereigns to international capital markets. Relying on annual data for a large panel of countries over the period 1970-2011, we find that, as the reputation of debtor countries as good (bad) borrowers solidifies over time, those episodes are more likely to end - i.e. the "legacy of time". Debtor countries can take advantage of the "benefit of doubt" of creditors during short exit spells. However, when exits are long and the reputation as a bad borrower emerges, no more "complacency" makes it more difficult for them to bo…

An Augmented Static Olley-Pakes Productivity Decomposition with Entry and Exit Measurement and Interpretation

2015

We develop an augmented Olley–Pakes (OP) decomposition that allows us to examine how entering and exiting firms contribute to the popular OP covariance measure of allocative efficiency. Applying the decomposition to a comprehensive micro-level data, we find that a large part of the OP covariance component can be attributed to entrants and exiting firms. We also build a model of firm dynamics that is consistent with our main empirical results. In the model economy, the standard OP covariance component tends to increase with certain type of distortions because of endogenous changes in firm entry and exit.

Spatial and sectoral effects on firm entry and exit. Evidence from Italy.

2012

Indicadores de la satisfacción con la vida en personas adultas mayores en Costa Rica y España

2018

Propósito: En el presente trabajo se indaga acerca de los principales indicadores de la satisfacción con la vida en personas mayores participantes de programas universitarios en España y Costa Rica. Método: Se emplea un diseño panel y se analiza el primer tiempo de recolección de datos. La muestra fue constituida por personas mayores de 55 o más años que estaban cursando estudios en diferentes centros de formación adscritos a la Universidad de Valencia en España (N=652) y a la Universidad Nacional en Costa Rica (N=272). Los datos fueron recogidos mediante un cuestionario con variables sociodemográficas, indicadores de participación social, Cuestionario de Apoyo Social Funcional Duke-UNC-11,…

Work-loss years among people diagnosed with diabetes: a reappraisal from a life course perspective

2018

Aims Early exit from the workforce has been proposed to be one of the unfavorable consequences of diabetes. We examined whether early exit from the workforce differed between persons who were and were not diagnosed with diabetes during their work career. Methods The cohort included 12,726 individuals of the Helsinki Birth Cohort Study, born between 1934 and 1944. Using data from nationwide registers, the cohort was followed up from early adulthood until they transitioned into retirement or died. Work- loss years were estimated using the restricted mean work years method. Results During a follow-up of 382,328 person-years for men and 349 894 for women, 36.8% transitioned into old age pension…

Exact simulation of first exit times for one-dimensional diffusion processes

2019

International audience; The simulation of exit times for diffusion processes is a challenging task since it concerns many applications in different fields like mathematical finance, neuroscience, reliability horizontal ellipsis The usual procedure is to use discretization schemes which unfortunately introduce some error in the target distribution. Our aim is to present a new algorithm which simulates exactly the exit time for one-dimensional diffusions. This acceptance-rejection algorithm requires to simulate exactly the exit time of the Brownian motion on one side and the Brownian position at a given time, constrained not to have exit before, on the other side. Crucial tools in this study …

Dealing with missing participants in the opening phases of a videoconference

2023

Abstract The paper explores the social interaction that takes place during the initial phases of videoconferences. The focus is on the problem of absent participants, which is often considered a reason for delaying the official beginning of the meeting. One of the resources that the participants have is to reach the absent participant by cellphone. We observed a recurrent pattern of action whereby one of the participants disengages from the video meeting to reach the missing person by phone. This negotiation process moves through four steps: (1) the detection of the problem, (2) the offer to call the missing person by one participant, (3) the acceptance of this offer by the moderator, and (…